TRAX Mouse, Unlabeled, Clone: 56, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611358
RNA-binding proteins, such as Translin, have numerous functions that include mRNA transport and translational regulation, as well as DNA rearrangement and repair. Translin has a ring-shaped structure that allows binding to single stranded DNA ends. It is localized in the cytoplasm and nucleus, however it does not have a nuclear targeting motif. Translin-associated factor X (TRAX), a member of the Translin protein family, contains six potential PKC phosphorylation sites, eight CK2 phosphorylation sites, and one N-glycosylation site. TRAX can bind to Translin, contains a bipartite nuclear targeting motif, and has a heptad repeat of hydrophobic amino acids which may be a leucine zipper domain. This latter domain may be important for the formation of TRAX homodimers or heterodimers with Translin. Both TRAX and Translin are co-expressed in many tissues and form a complex with the GS1-DNA complex which is enriched in brain. Thus, TRAX may be involved with the nuclear transport of Translin, along with other important roles in regulating RNA transport and translation in a fashion similar to other RNA-binding proteins.
Immunofluorescence, Western Blotting
|Immunofluorescence, Western Blot|
|Human TRAX aa. 1-207|
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