Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

TREX1 Mouse anti-Mouse, Unlabeled, Clone: 29, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611986

 View more versions of this product

Catalog No. BDB611986

Add to cart



DNA replication, repair, and recombination requires the excision of nucleotides from the DNA 3 ft. termini. Many 3 ft. to 5 ft. exonucleases have been identified which catalyze the excision of monophosphates from the 3 ft. termini of DNA. TREX1 and TREX2 are 3 ft. to 5 ft. exonucleases that contain three conserved exonuclease active site motifs (EASM) that may produce exonuclease activity. TREX1 and TREX2 are most closely related to the proofreading exonucleases of the bacterial replicative DNA polymerases and the RNase T enzymes. Recombinant expression of TREX1 and TREX2 demonstrates that they have exonuclease activity when oligonucleotide is present. TREX1 shows the greatest exonuclease activity with partial duplex DNA, and no activity with single-stranded RNA or an RNA-DNA partial duplex. In addition, reconstitution of TREX1 with DNA polymerase β and DNA ligase III-XRCC1 facilitates accurate rejoining of a 3 ft. mismatched base residue at a single-strand break. Thus, TREX1 and TREX2 are 3 ft. to 5 ft. exonucleases that may be important for excision of nucleotides during DNA replication, repair, and recombination.

Host Species: Mouse
Clone: 29
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Mouse TRE1 aa. 82-179

Immunofluorescence, Western Blotting



Affinity Purified
Mouse TRE1 aa. 82-179
Cell Biology
Western Blot
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Store undiluted at -20°C.
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit

For Research Use Only.