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  6. TREX1 Mouse anti-Mouse, Unlabeled, Clone: 29, BD

TREX1 Mouse anti-Mouse, Unlabeled, Clone: 29, BD

Catalog No. BDB611986 Shop All BD Biosciences Products
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Catalog No. BDB611986 Supplier BD Biosciences Supplier No. 611986
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Description

Mouse Monoclonal Antibody

DNA replication, repair, and recombination requires the excision of nucleotides from the DNA 3′ termini. Many 3′ to 5′ exonucleases have been identified which catalyze the excision of monophosphates from the 3′ termini of DNA. TREX1 and TREX2 are 3′ to 5′ exonucleases that contain three conserved exonuclease active site motifs (EASM) that may produce exonuclease activity. TREX1 and TREX2 are most closely related to the proofreading exonucleases of the bacterial replicative DNA polymerases and the RNase T enzymes. Recombinant expression of TREX1 and TREX2 demonstrates that they have exonuclease activity when oligonucleotide is present. TREX1 shows the greatest exonuclease activity with partial duplex DNA, and no activity with single-stranded RNA or an RNA-DNA partial duplex. In addition, reconstitution of TREX1 with DNA polymerase β and DNA ligase III-XRCC1 facilitates accurate rejoining of a 3′ mismatched base residue at a single-strand break. Thus, TREX1 and TREX2 are 3′ to 5′ exonucleases that may be important for excision of nucleotides during DNA replication, repair, and recombination.

Host Species: Mouse
Clone: 29
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Mouse TRE1 aa. 82-179

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen TREX1
Applications Western Blot
Classification Monoclonal
Clone 29
Concentration 250μg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Mouse TRE1 aa. 82-179
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.

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