Invitrogen™ TSLP Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520321

Catalog No. PIPA520321

Description

Despite its predicted molecular weight, TSLP often migrates at a higher molecular weight in SDS-PAGE. A suggested positive control is A-20 cell lysate. PA5-20321 can be used with blocking peptide PEP-0441.

TSLP is a 159 amino acid four helix-bundle hemopoietic cytokine that signals through a heterodimeric receptor complex consisting of the human TSLP receptor and the IL-7R alpha-chain. It impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes, enhances the maturation of CD11c (+) dendritic cells, naive CD4 (+), and CD8 (+) T cells into proallergic effectors, and primes dendritic cells to produce large amounts of IL-12 after CD40 ligand stimulation. TSLP influences the regulation of the positive selection of regulatory T cells and maintenance of peripheral CD4 (+) T cell homeostasis. It induces allergic inflammation by directly activating mast cells and may be involved in the pathophysiology of inflammatory arthritis. It is expressed in heart, liver and prostate.

Specifications

• Antigen: TSLP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TSLP
• Gene Alias: Thymic stroma-derived lymphopoietin; thymic stromal lymphopoietin; TSLP
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 53603, 688621
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunohistochemistry (PFA fixed), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q9JIE6
• Gene Symbols: TSLP
• Immunogen: A 20 amino acid peptide from near the center of mouse TSLP.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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