TSLP Receptor Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520378
Despite its predicted molecular weight, TSLP-R often migrates at a higher molecular weight in SDS-PAGE. A suggested positive control is human liver tissue lysate. PA5-20378 can be used with blocking peptide PEP-0495.Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintece of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells; co-transfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1.
|A 19 amino acid peptide from near the center of human TSLP receptor.|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|WI2-87105E3.1, CRL2, CRLF2Y, TSLPR; IL-XR; P2RY8/CRLF2 fusion; TSLP receptor; cytokine receptor CRL2 precusor; cytokine receptor-like 2; thymic stromal lymphopoietin protein receptor; thymic stromal lymphopoietin receptor; thymic stromal-derived lymphopoietin receptor|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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