anti-TTN, Clone: 2B3, Abnova

Catalog No.	Quantity
89-001-035	100 μg

Catalog No. 89-001-035 Supplier Abnova Corporation Supplier No. H00007273M02

Description

Mouse Monoclonal

This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. A N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere respectively so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Of the many titin variants identified, five for which complete transcript information is available are described. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9 and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma.

ELISA, Immunofluorescence, Immunohistochemistry (Paraffin), Sandwich ELISA, Western Blotting

Specifications

• Antigen: titin
• Applications: ELISA, Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
• Classification: Monoclonal
• Clone: 2B3
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against a partial recombinant TTN.
• Formulation: PBS with no preservative; pH 7.4
• Gene: TTN
• Gene Accession No.: BC058824
• Gene Alias: CMD1G/CMH9/CMPD4/CONNECTIN/DKFZp451N061/EOMFC/FLJ26020/FLJ26409/FLJ32040/FLJ34413/FLJ39564/FLJ43066/HMERF/LGMD2J/TMD
• Gene Symbols: TTN
• Host Species: Mouse
• Immunogen: TTN (AAH58824, 1 a.a. ∼ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Purification Method: Affinity Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Whole Molecule: Yes
• Primary or Secondary: Primary
• Gene ID (Entrez): 7273
• Target Species: Human
• Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Product Type: Antibody
• Isotype: IgG1 κ