TWEAK Mouse anti-Human, NA/LE, Unlabeled, Clone: CARL-1, BD

Catalog No.	Quantity
BDB562203	0.5 mg

Catalog No. BDB562203 Supplier BD Biosciences Supplier No. 562203

Description

Mouse Monoclonal Antibody

The CARL-1 monoclonal antibody specifically binds to CD255, also known as TWEAK (TNF-related WEAK inducer of apoptosis). The CD255 cytokine belongs to the tumor necrosis factor (TNF) ligand family and is encoded by the TNFSF12 ( Tumor necrosis factor ligand superfamily member 12 ) gene. CD255 (TWEAK) is present as a type II transmembrane protein form and a smaller, biologically-active secreted isoform. CD255 is expressed on most tissues and non-lymphoid tumor cell lines but has weak or no expression on hematopoietic lineage cell lines. CD255 is not detectable on resting peripheral blood mononuclear cells. However, its expression is upregulated on peripheral blood monocytes in response to IFN- γstimulation. CD255 can act through the TWEAK Receptor (aka, TWEAK-R, TNFRSF12A, Fn14, and CD266) to induce a variety of target cellular responses including NF-kB activation, proliferation, apoptosis, IL-8 and GM-CSF production. Clone CARL-2, a different monoclonal antibody, also binds to TWEAK although it binds to a different TWEAK epitope.

Specifications

• Antigen: TWEAK
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: CARL-1
• Concentration: 1.0mg/mL
• Conjugate: Unconjugated
• Description: CD255; TWEAK; TNFSF12; APO3 ligand; APO3L; DR3LG
• Formulation: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
• Host Species: Mouse
• Immunogen: Human Transfected Cell Line
• Purification Method: Affinity Purified
• Quantity: 0.5 mg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Store undiluted at 4°C
• Isotype: IgG3 κ