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TWEAK Mouse anti-Human, PE, Clone: CARL-1, BD

Catalog No. BDB552831 Shop All BD Biosciences Products
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BDB552831 100 Tests
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Catalog No. BDB552831 Supplier BD Biosciences Supplier No. 552831

Description

Mouse Monoclonal Antibody

Reacts with TWEAK, or TNF-like weak inducer of apoptosis, a type II transmembrane protein of approximately 1.4 kDa. It is present as a cell surface bound or a secreted form, expressed on most tissues and non-lymphoid tumor cell lines, but weak or no expression on hematopoietic lineage lines. TWEAK is not detectable on resting PBMC, but its expression on peripheral blood monocytes is upregulated upon IFN-g stimulation. Reports indicate that TWEAK interacts with its receptor APO-3 and this interaction can lead to apoptosis, IL-8 secretion, NF-kB activation and endothelial cell proliferation. Clone CARL-2, a different monoclonal antibody, also reacts with TWEAK but to a different epitope.

Host Species: Mouse
Clone: CARL-1
Isotype: IgG3 κ
Species Reactivity: Human

Flow Cytometry

TRUSTED_SUSTAINABILITY

Specifications

Antigen TWEAK
Applications Flow Cytometry
Classification Monoclonal
Clone CARL-1
Conjugate PE
Description CD255; TWEAK; TNFSF12; APO3 ligand; APO3L; DR3LG
Formulation Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human Tweak Transfected Cell Line
Purification Method Affinity Purified
Quantity 100 Tests
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG3 κ
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For Research Use Only.

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