Tyk2 (pY1054/pY1055) Mouse anti-Human, Unlabeled, Clone: I114-617, BD

Catalog No.	Quantity
BDB558394	0.1 mg

Catalog No. BDB558394 Supplier BD Biosciences Supplier No. 558394

Description

Mouse Monoclonal Antibody

Tyk2 is a widely expressed protein tyrosine kinase (PTK) of 1187 amino acids (135kDa). The N-terminal kinase-related domain of Tyk2 shows 54% identity to the kinase-related domain of the JAK1 kinase. Surprisingly, the catalytic region of JAK1 shares more sequence identity to Tyk2 than it does with JAK2 kinase. The similarity of structure between Tyk2 and JAK1 suggests that both may be involved in related phosphorylation cascades. Tyk2 plays a critical role in the interferon (IFN)-a/b response while JAK1 shows involvement in both the IFN- α/β and IFN-γ signal transduction pathways. JAK2, however, appears to be required only in the IFN-g response. It has been suggested that a portion of the large extracatalytic domain of Tyk2 could interact with components of the IFN a/b receptor. The I114-617 monoclonal antibody recognizes the phosphorylated Y1054 and Y1055 in the tyrosine kinase domain of Tyk2.

Western Blotting

Specifications

• Antigen: Tyk2 (pY1054/pY1055)
• Applications: Western Blot
• Classification: Monoclonal
• Clone: I114-617
• Concentration: 0.5mg/mL
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Host Species: Mouse
• Immunogen: Phosphorylated peptide of the region including the tyrosines 1054 and 1055 of human Tyk2
• Purification Method: Affinity Purified
• Quantity: 0.1 mg
• Regulatory Status: RUO
• Research Discipline: Cell Biology
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Store undiluted at 4°C
• Isotype: IgG1 κ