MilliporeSigma™ anti-Tyrosine Hydroxylase Alexa Fluor 488, Clone: LNC1,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MAB318AF488

Catalog No. MAB318AF488

Description

Specifically detects Tyrosine Hydroxylase Clone: LNC1 in Chicken, Frog, Human, Mouse, Rat, Zebrafish samples, and it is validated for Immunocytochemistry

Tyrosine 3-monooxygenase (EC 1.14.16.2; UniProt P07101; also known as Dystonia 14, TH, Tyrosine 3-hydroxylase) is encoded by the TH (also known as DYT14, DYT5b, TYH) gene (Gene ID 7054) in human. Tyrosine hydroxylase plays an important role in the physiology of adrenergic neurons. It is the first and rate-limiting enzyme involved in the biosynthesis of the catecholamines Dopamine and Norepinephrine from tyrosine. TH is, therefore, a useful marker for dopaminergic and noradrenergic neurons. TH enzymatic activity requires ferrous ions as cofactors and is believed to be regulated by phosphorylation. Six isoforms of human TH exist as a result of alternative splicing (UniProt P07101-1 through P07101-6).

Specifications

• Antigen: Tyrosine Hydroxylase
• Classification: Monoclonal
• Conjugate: Alexa Fluor 488
• Gene Accession No.: P07101
• Host Species: Mouse
• Purification Method: Protein A purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Recognizes an epitope on the outside of the regulatory N-terminus of tyrosine hydroxylase. Does not react with dopamine-beta-hydroxylase, phenylalanine hydroxylase, trytophan hydroxylase, dehydropteridine reductase, sepiapterin reductase, or phenethanolamine-N-methyl transferase (PNMT) by Western blotting using the unconjugated antibody.
• Content And Storage: 2°C to 8°C for one year from date of shipment
• Isotype: IgG1 κ

• Applications: Immunocytochemistry
• Clone: LNC1
• Formulation: Purified mouse antibody conjugate in PBS with 15mg/mL BSA and 0.1 % sodium azide.
• Gene Symbols: TH, TYH
• Immunogen: Tyrosine Hydroxylase purified from PC12 cells.
• Quantity: 100 μL
• Research Discipline: Neuroscience
• Gene ID (Entrez): NM_000360.3
• Target Species: Chicken, Frog, Human, Mouse, Rat, Zebrafish
• Form: Purified

For Research Use Only