Tyrosine Hydroxylase Mouse anti-Rat, Unlabeled, Clone: TOH A1, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 556311

Catalog No. BDB556311

Description

The catecholamine neurotranmitters, dopamine, noradrenaline and adrenaline, are involved in multiple physiological processes and neurological disorders. These three transmitters are synthesized from the amino acid tyrosine in a common pathway that uses five enzymes: tyrosine hydroxylase, aromatic amino acid decarboxylase, dopamine β hydroxylase, pteridine reductase, and phenylethanolamine-N-methyl transferase. Tyrosine hydroxylase, is the rate-limiting enzyme in catecholamine synthesis. It converts tyrosine to L-dihydroxyphenylalanine (L-DOPA), which is then further converted to give rise to dopamine, noradrenaline and adrenaline. Antibodies against these biosynthetic enzymes have been widely used in the immunohistochemical analysis of catecholaminergic neurons. TOH A1 specifically reacts with rat tyrosine hydroxylase and can be used to identify tyrosine hydroxylase containing catecholaminergic neurons in rat brain.

Host Species: Mouse
Clone: TOH A1
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Tyrosine hydroxylase purified from the PC12 rat pheochromocytoma cell line

Electron Microscopy, Immunohistochemistry (Frozen)

Specifications

• Antigen: Tyrosine Hydroxylase
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Tyrosine hydroxylase purified from the PC12 rat pheochromocytoma cell line
• Quantity: 0.1 mg
• Research Discipline: Cell Biology
• Target Species: Rat
• Isotype: IgG1

• Applications: Immunohistochemistry (Frozen)
• Clone: TOH A1
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

For Research Use Only.