UbcH7 Mouse, Unlabeled, Clone: 20, BD

Catalog No.	Quantity
BDB610852	50 μg
BDB610853	150 μg

Catalog No. BDB610852 Supplier BD Biosciences Supplier No. 610852

Description

Mouse Monoclonal Antibody

Progression of the mammalian cell cycle is regulated mainly by phosphorylation/dephosphorylation and synthesis/degradation of many key proteins. Ubiquitin, a soluble protein of 76 amino acids, is enzymatically attached to an ε -NH2-Lys in a target protein. Ubiquitination is a hallmark for rapid protein degradation of the target protein in the proteosome-a cytoplasmic complex of proteases. Several human homologs of the yeast ubiquitin-conjugating enzymes (Ubc) have been identified and found involved in critical processes such as cell cycle progression and apoptosis. UbcH7 was characterized as an E6-AP-interacting protein required for the ubiquitination of p53. E6-AP is the ubiquitin ligase used as bait in the search for interacting proteins required for the proper ubiquitination of cellular targets. UbcH7 interacts with the C-terminal region of E6-AP named the hect domain. Therefore, UbcH7 is another protein, like Ubc9, involved in the degradation and regulation of critical proteins in the cell cycle.

Specifications

• Antigen: UbcH7
• Applications: Immunofluorescence, Western Blot
• Classification: Monoclonal
• Clone: 20
• Concentration: 250μg/mL
• Conjugate: Unconjugated
• Description: Ubiquitin Conjugating Enzyme H7
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Host Species: Mouse
• Immunogen: Human UbcH7 aa. 15-133
• Purification Method: Affinity Purified
• Quantity: 50 μg
• Regulatory Status: RUO
• Research Discipline: Cell Biology
• Primary or Secondary: Primary
• Target Species: Canine, Frog, Human, Mouse, Rat
• Content And Storage: Store undiluted at -20°C.
• Isotype: IgG1

For Research Use Only.