MilliporeSigma™ anti-Ubiquitin, Polyclonal

Catalog No.	Quantity	Conjugate
66-209-950UL	50 μL	Unconjugated

Catalog No. 66-209-950UL Supplier MilliporeSigma™ Supplier No. 66209950UL

Description

Rabbit Polyclonal Antibody

Specifically detects Ubiquitin Clone: in Bovine, Canine, Chicken, Drosophila, E. coli, Frog, Guinea Pig, Hamster, Human, Monkey, Mouse, Rabbit, Rat, Sheep, Yeast samples, and it is validated for Immunohistochemistry, Immunoprecipitation

Ubiquitin is a highly conserved protein that functions in intracellular regulation. The ubiquitin system is the major pathway for selective protein degradation and is responsible for the degradation of abnormal and short-lived proteins. In the first step, ubiquitin is activated in an ATP-dependent reaction by ubiquitin-activating enzyme (E1). Activated ubiquitin is transferred to a ubiquitin conjugating enzyme (E2), then transferred to a protein substrate with the aid of ubiquitin-protein ligase (E3). An isopeptide linkage is formed between the C-terminus of the ubiquitin and an internal lysine residue of the substrate protein. Degradation requires the presence of a multi-ubiquitin chain on a substrate, which targets the protein for degradation by the 26S proteasome. Ubiquitin molecules are then released and recycled.

Specifications

• Antigen: Ubiquitin
• Applications: Immunohistochemistry, Immunoprecipitation
• Classification: Polyclonal
• Conjugate: Unconjugated
• Host Species: Rabbit
• Immunogen: bovine erytherocyte ubiquitin conjugated to KLH
• Quantity: 50 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Recognizes the ∽8.6kDa unconjugated and various forms of conjugated ubiquitin.
• Target Species: Bovine, Canine, Chicken, Drosophila, E. coli, Frog, Guinea Pig, Hamster, Human, Monkey, Mouse, Rabbit, Rat, Sheep, Yeast
• Content And Storage: −20°C
• Form: Undiluted
• Isotype: IgG

For Research Use Only