Ubiquitin Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA126088
PA1-26088 detects Ubiquitin from human and mouse samples. PA1-26088 has been successfully used in immunoprecipitation, immunohistochemistry and Western blot procedures. The PA1-26088 immunogen is full length native Ubiquitin protein purified from bovine red blood cells. Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.Ubiquitin is a highly conserved protein of about 8.5 kDa molecular weight, which has an ATP dependent role in the targeting of proteins for proteolytic degradation. To perform this function, the protein to be degraded is first covalently attached to the C terminus of ubiquitin, and the ubiquitinated complex is then recognized by a complex of degradative enzymes. Interestingly, ubiquitin also becomes covalently bonded to many types of pathological inclusions, which appear to be resistant to normal degradation. Therefore, ubiquitin antibodies are very useful for studies of these inclusions. For example, the neurofibrillary tangles and paired helical filaments diagnostic of Alzheimer ft.s disease, Lewy bodies seen in Parkinson ft.s disease, and Pick bodies found in Pick ft.s disease are all heavily ubiquitinated and can be readily visualized with ubiquitin antibodies.
|whole serum with no preservative|
|Ubiquitin B, Polyubiquitin B, polyubiquitin-B, ubiquitin|
|Immunohistochemistry, Immunoprecipitation, Western Blot|
|Full length native Ubiquitin protein purified from bovine red blood cells.|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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