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Ufd2/E4 Mouse, Unlabeled, Clone: 7, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611966

Catalog No. BDB611966

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Maintenance of cellular function requires timely and selective degradation of key regulatory proteins. For example, progression of the mammalian cell cycle is regulated by phosphorylation/dephosphorylation and synthesis/degradation of many key proteins via the ubiquitin pathway. Ubiquitin, a soluble protein of 76 amino acids, is enzymatically attached to an ε-NH2-Lys in a target protein. Ubiquitin-conjugated proteins are recognized and degraded by the 26S proteasome. Ubiquitination requires ubiquitin-activating enzyme E1, ubiquitin conjugating enzymes E2, and ubiquitin ligases E3. The direction of ubiquitin transfer is from E1 to E2 and from E2 to E3. The human homologue of the yeast Ufd2, Ufd2/E4, may function as a fourth step (E4 ubiquitin enzyme) that facilitates multichain assembly. Long ubiquitin chain formation may be required for rapid protein degradation by the 26S proteasome. Ufd2/E4 contains a conserved ubiquitin binding domain (U-box) in the C-terminal region, which is also found in homologues in yeast (Ufd2) and Dictyostelium (NOSA). In addition to its role in ubiquination, the aberrant expression of a mutant Ufd2/D4Cole1e fusion protein has been implicated in slow wallerian degeneration mice.

Host Species: Mouse
Clone: 7
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human Ufd2/E4 aa. 1034-1241

Immunofluorescence, Western Blotting

Specifications

Specifications

Ufd2/E4
7
Unconjugated
Murine
IgG1
RUO
Primary
Human, Murine, Rat
Immunofluorescence, Western Blot
250μg/mL
Affinity Purified
Human Ufd2/E4 aa. 1034-1241
50μg
Cell Biology
Monoclonal
Documents
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