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Ufd2/E4 Mouse, Unlabeled, Clone: 7, BD

Catalog No. BDB611966 Shop All BD Biosciences Products
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BDB611966 50 μg
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Catalog No. BDB611966 Supplier BD Biosciences Supplier No. 611966

Description

Mouse Monoclonal Antibody

Maintenance of cellular function requires timely and selective degradation of key regulatory proteins. For example, progression of the mammalian cell cycle is regulated by phosphorylation/dephosphorylation and synthesis/degradation of many key proteins via the ubiquitin pathway. Ubiquitin, a soluble protein of 76 amino acids, is enzymatically attached to an ε-NH2-Lys in a target protein. Ubiquitin-conjugated proteins are recognized and degraded by the 26S proteasome. Ubiquitination requires ubiquitin-activating enzyme E1, ubiquitin conjugating enzymes E2, and ubiquitin ligases E3. The direction of ubiquitin transfer is from E1 to E2 and from E2 to E3. The human homologue of the yeast Ufd2, Ufd2/E4, may function as a fourth step (E4 ubiquitin enzyme) that facilitates multichain assembly. Long ubiquitin chain formation may be required for rapid protein degradation by the 26S proteasome. Ufd2/E4 contains a conserved ubiquitin binding domain (U-box) in the C-terminal region, which is also found in homologues in yeast (Ufd2) and Dictyostelium (NOSA). In addition to its role in ubiquination, the aberrant expression of a mutant Ufd2/D4Cole1e fusion protein has been implicated in slow wallerian degeneration mice.

Host Species: Mouse
Clone: 7
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human Ufd2/E4 aa. 1034-1241

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen Ufd2/E4
Applications Immunofluorescence, Western Blot
Classification Monoclonal
Clone 7
Concentration 250μg/mL
Conjugate Unconjugated
Host Species Mouse
Immunogen Human Ufd2/E4 aa. 1034-1241
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human, Mouse, Rat
Isotype IgG1
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