UHRF1 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA527969
PA5-27969 targets UHRF1 in IF, IHC (P), and WB applications and shows reactivity with Human samples. The PA5-27969 immunogen is recombit fragment corresponding to a region within amino acids 51 and 516 of Human UHRF1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.
|Recombit fragment corresponding to a region within amino acids 51 and 516 of Human UHRF1|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7|
|ICBP90, Np95, RNF106, hNP95, E3 ubiquitin-protein ligase UHRF1, RING finger protein 106, huNp95, inverted CCAAT box-binding protein of 90 kDa, nuclear protein 95, nuclear zinc finger protein Np95, transcription factor ICBP90, ubiquitin-like PHD and RING finger domain-containing protein 1, ub|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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