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UNC93B1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523196

Catalog No. PIPA523196


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Description

Description

UNC93B is a member of a novel hUNC93B-related gene family and encodes a 12-membrane-spanning protein related to unc-93 of Caenorhabditis elegans. The protein is involved in the regulation or coordination of muscle contraction in the worm. The protein is also necessary for TLR signaling and for the presentation and cross-presentation of exogenous antigens. The protein specifically interacts with TLR3, 7, 9, and 13 and introduction of point mutation H412R in UNC93B abolishes these interactions. Mutation in the missense allele of UNC93B, 3d disrupts exogenous antigen presentation and signaling via TLR. The pathological role of the protein has been identified in susceptibility to herpes simplex encephalitis (HSE). In human the protein is expressed in heart and at lower levels in kidney. In mouse the gene is localized in the chromosomal region 19 A.
Specifications

Specifications

UNC93B1
Polyclonal
Unconjugated
UNC93B1
Liquid
UNC93B1
Synthetic peptide (518 LQQGLVPRQPRIPKP 532) of UNC93B protein.
Protein G
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
1.0 mg/mL
PBS with 0.05% sodium azide
Q9H1C4, Q8VCW4
IIAE1, UNC93, UNC93B, Unc-93B1, hUNC93B1, protein unc-93 homolog B1, unc-93 related protein, unc93 homolog B, unc93 homolog B1
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
361689, 54445, 81622
Documents
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