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VEGFR-3 Rat anti-Mouse, Unlabeled, Clone: AFL4, BD

Catalog No. BDB552857 Shop All BD Biosciences Products
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Catalog No. BDB552857 Supplier BD Biosciences Supplier No. 552857
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Description

Rat Monoclonal Antibody

The AFL4 antibody reacts with mouse VEGFR-3, an endothelial-specific receptor tyrosine kinase (RTK) related to VEGF receptors. The immunogen used was the extracellular domain of VEGFR-3, corresponding to nucleotides 45-2354 in the GeneBank L07296. VEGFR-3 is induced in all endothelial cells (ECα) during early embryogenesis, and its expression eventually disappears from the vascular endothelial cells of adult tissues. VEGFR-3 is constitutively expressed in the adult lymphatic endothelium. Although VEGFR-3 is not expressed in adult blood vessels, it is induced in vascular endothelial cells of tumor-bearing tissues. Studies have shown that both VEGF-C and VEGF-D, ligands for VEGFR-3, promote lymphatic vessel proliferation throughout central tumor areas and at their peripheries, demonstrating that such molecules aid in the spread of tumor cells from the primary tumor to local lymph nodes.

Host Species: Rat
Clone: AFL4
Isotype: IgG2a κ
Species Reactivity: Mouse
Immunogen: VEGFR-3 extracellular domain

Immunohistochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen VEGFR-3
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone AFL4
Conjugate Unconjugated
Formulation Aqueous buffered solution containing BSA, goat serum, and ≤0.09% sodium azide.
Host Species Rat
Immunogen VEGFR-3 extracellular domain
Purification Method Affinity Purified
Quantity 1 mL
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C
Isotype IgG2a κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.

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