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VHL Mouse anti-Human, Alexa Fluor 647, Clone: S2-647, BD

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BDB564184 50 Tests
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Catalog No. BDB564184 Supplier BD Biosciences Supplier No. 564184
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Description

Mouse Monoclonal Antibody

The S2-647 monoclonal antibody recognizes the Von Hippel-Lindau (VHL) protein. The VHL protein is expressed within the cytosol and nuclei of cells from a variety of tissues. It serves as a tumor suppressor and transcriptional repressor that is highly conserved from Drosophila to mammalian species. VHL binds to Elongin B and C subunits and other proteins as part of a E3 ubiquitin ligase complex that targets a variety of proteins, including HIF-1 alpha and Beta-2 adrenergic receptors, for proteasomal degradation. Aberrant VHL expression is associated with a number of diseases including Von Hippel-Lindau disease, a familial cancer syndrome, that predisposes individuals to hemangioblastomas of the central nervous system and retina, pheochromocytoma and renal cell carcinoma. Three distinct VHL isoforms ranging in molecular weight from approximately 19-30 kDa have been described.

TRUSTED_SUSTAINABILITY

Specifications

Antigen VHL
Applications Flow Cytometry
Classification Monoclonal
Clone S2-647
Conjugate Alexa Fluor 647
Description VHL1; pVHL; Elongin binding protein; Protein G7; HRCA1; RCA1
Host Species Mouse
Immunogen Human VHL Recombinant Protein
Purification Method Affinity Purified
Quantity 50 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2b κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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