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VHL Mouse anti-Human, Unlabeled, Clone: S2-647, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 564183

Catalog No. BDB564183


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Description

Description

The S2-647 monoclonal antibody recognizes the Von Hippel-Lindau (VHL) protein. The VHL protein is expressed within the cytosol and nuclei of cells from a variety of tissues. It serves as a tumor suppressor and transcriptional repressor that is highly conserved from Drosophila to mammalian species. VHL binds to Elongin B and C subunits and other proteins as part of a E3 ubiquitin ligase complex that targets a variety of proteins, including HIF-1 alpha and Beta-2 adrenergic receptors, for proteasomal degradation. Aberrant VHL expression is associated with a number of diseases including Von Hippel-Lindau disease, a familial cancer syndrome, that predisposes individuals to hemangioblastomas of the central nervous system and retina, pheochromocytoma and renal cell carcinoma. Three distinct VHL isoforms ranging in molecular weight from approximately 19-30 kDa have been described.

TRUSTED_SUSTAINABILITY
Specifications

Specifications

VHL
Monoclonal
0.5mg/mL
VHL1; pVHL; Elongin binding protein; Protein G7; HRCA1; RCA1
Human VHL Recombinant Protein
0.1 mg
Primary
Store undiluted at 4°C
Flow Cytometry
S2-647
Unconjugated
Mouse
Affinity Purified
RUO
Human
IgG2b κ
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