MilliporeSigma™ anti-Vinculin Clone: V284 or VLN01,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ CP74100UG

Catalog No. CP74100UG

Description

Specifically detects Vinculin Clone: V284 or VLN01 in Human samples, and it is validated for Immunohistochemistry (Paraffin), Immunoprecipitation

Vinculin is an attachment protein involved in the indirect binding of intracellular actin filaments to extracellular fibronectin. Vinculin binds to actin capping protein and α-actinin, which in turn binds to actin. Also, vinculin binds to talin, which in turn binds to the intracellular domain of the fibronectin receptor. Vinculin has been associated with tumor suppressor activity. Vinculin is widely distributed in tissues and expressed where smooth muscle actin and fibroblasts attach to the extracellular matrix. Vinculin has been found in all adherens junctions, while the larger splice variant, meta-vinculin, is found only in smooth and cardiac muscle.

Specifications

• Antigen: Vinculin
• Classification: Monoclonal
• Conjugate: Unconjugated
• Host Species: Mouse
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Form: Purified

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation
• Clone: V284 or VLN01
• Formulation: In 10mM PBS, 0.2% BSA, pH 7.4.
• Immunogen: semi-purified, human vinculin
• Regulatory Status: RUO
• Test Specificity: Recognizes the ∽130 (vinculin) and ∽150kDa (meta-vinculin) proteins in skin tissue.
• Content And Storage: 2°C to 8°C
• Isotype: IgG1

For Research Use Only