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MilliporeSigma™ anti-Vinculin Clone: V284 or VLN01,

Catalog No. CP74100UG Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
CP74100UG 100 μg Unconjugated
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Catalog No. CP74100UG Supplier MilliporeSigma™ Supplier No. CP74100UG
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Description

Mouse Monoclonal Antibody

Specifically detects Vinculin Clone: V284 or VLN01 in Human samples, and it is validated for Immunohistochemistry (Paraffin), Immunoprecipitation

Vinculin is an attachment protein involved in the indirect binding of intracellular actin filaments to extracellular fibronectin. Vinculin binds to actin capping protein and α-actinin, which in turn binds to actin. Also, vinculin binds to talin, which in turn binds to the intracellular domain of the fibronectin receptor. Vinculin has been associated with tumor suppressor activity. Vinculin is widely distributed in tissues and expressed where smooth muscle actin and fibroblasts attach to the extracellular matrix. Vinculin has been found in all adherens junctions, while the larger splice variant, meta-vinculin, is found only in smooth and cardiac muscle.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Vinculin
Applications Immunohistochemistry (Paraffin), Immunoprecipitation
Classification Monoclonal
Clone V284 or VLN01
Conjugate Unconjugated
Formulation In 10mM PBS, 0.2% BSA, pH 7.4.
Host Species Mouse
Immunogen semi-purified, human vinculin
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽130 (vinculin) and ∽150kDa (meta-vinculin) proteins in skin tissue.
Target Species Human
Content And Storage 2°C to 8°C
Form Purified
Isotype IgG1
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For Research Use Only

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