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Viperin Rabbit anti-Bovine, Canine, Chicken, Equine, Hamster, Human, Mouse, Non-human primate, Porcine, Rabbit, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523508

Catalog No. PIPA523508


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Description

Description

Viperin is a 43kDa protein which is one of several hundred interferon inducible viral proteins. Elevated expression of viperin is induced by LPS and poly I:C through TLR dependent signaling pathways.  Sendai virus mediated viperin expression is induced independently of TLR signaling pathways through  RLRs - RIG-I and MAVs (Severa, 2006).  Viperin has been shown to play an important role in interferon mediated  anti-viral activity in a Hepatitis C virus model system (Helbig, 2011). Viperin is induced in lymphoid cells and dendritic cells (DCs) and  highly induced  in neutrophils and macrophages during acute LCMV infection in mice (Hinson, ).   Viperin functions as a mediator of viral resistance and as a marker for interferon responsiveness making its detection and mechanism of action through specific antibody probes valuable for further studies.  Additionally, viperin  antibodies provide useful information for analysis of specific cell types responsive to interferon making it valuable for phenotyping studies complementing mechanism of action analysis.
Specifications

Specifications

Viperin
Polyclonal
Unconjugated
RSAD2
Liquid
RSAD2
Portion of amino acids 165-215 of human viperin
Protein A
RUO
Antibody
Polyclonal
Bovine, Canine, Chicken, Equine, Hamster, Human, Mouse, Non-human primate, Porcine, Rabbit, Rat
Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q2HJF9, Q8WXG1, Q8CBB9, Q9MZU4, O70600
2510004L01Rik, cig33, cig5, vig1, cytomegalovirus-induced gene 5 protein, radical S-adenosyl methionine domain-containing protein 2, viperin, virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
100072610, 100347276, 100753921, 396752, 428650, 506415, 58185, 609005, 65190, 91543
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