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Wnt16 w/control Mouse anti-Human, Unlabeled, Clone: F4-1582, BD

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BDB552595 50 μg
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Catalog No. BDB552595 Supplier BD Biosciences Supplier No. 552595

Description

Mouse Monoclonal Antibody with Control

The Wnt gene family comprises a large group of signaling proteins involved in developmental pathways in vertebrates, Drosophilia, C. elegans and other organisms. The Wnt genes were first discovered in mouse (called int-1) and later in Drosophilia (called wingless, or wg) where the signaling pathways were unravelled. The Wnt proteins are involved in various developmental processes including embryonic induction, generation of cell polarity and the specification of cell fate. The vertebrate Wnt glycoproteins number at least 16 members and initiate signaling by being secreted and a subset of these glycoproteins bind to a class of receptors, called Frizzled, of which 11 have been identified. Stimulation of the Wnt pathway causes the phosphorylation of Dishevelled, which inhibits glycogen synthase kinase -3β (GSK3β) and allows β-catenin to accumulate in the cytosol. β-catenin then translocates to the nucleus to form a complex with Tcf/LEF family of transcription factors to activate transcription. In unstimulated cells, β-catenin forms a complex with the proteins Axin, adenomatous polyposis coli (APC), (GSK3β) and is unstable. Studies have shown that some members of this pathway become mutated in human cancers, such as colon carcinoma and melanoma. Futhermore, studies on the WNT-16 gene, have shown that it is activated by the E2A-Pbx fusion product in acute lymphoblastoid leukemia. Wnt16 has a predicted molecular weight of 40kDa (SWISS-PROT:Q9UBV4).

Host Species: Mouse
Clone: F4-1582
Isotype: IgG2b κ
Species Reactivity: Human
Immunogen: Human WNT16 Recombinant Protein
Formula Weight [Chemical]: 40kDa

Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen Wnt16 w/control
Applications Western Blot
Classification Monoclonal
Clone F4-1582
Concentration 0.5mg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human WNT16 Recombinant Protein
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at -20°C.
Isotype IgG2b κ
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For Research Use Only.

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