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WWOX Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA131218

Catalog No. PIPA131218


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Description

Description

PA1-31218 detects WWOX2 from human, rat, mouse samples. PA1-31218 has been successfully used in ELISA applications. The PA1-31218 immunogen is: Synthetic peptide.

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.
Specifications

Specifications

WWOX
Polyclonal
Unconjugated
WWOX
Liquid
WWOX
Synthetic peptide.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
ELISA
0.5 mg/mL
Antibody with no preservative
Q9NZC7, Q91WL8
D16S432E, FOR, FRA16D, HHCMA56, PRO0128, SDR41C1, WOX1
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
292041, 51741, 80707
Documents
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