XBP1, Rabbit, Monoclonal Antibody, Abnova™

Catalog No.	Quantity
89-200-788	1 mg x up to 3 Abs

Catalog No. 89-200-788 Supplier Abnova Corporation Supplier No. H00007494K

Description

Includes

Up to three rabbit IgG clones of 1mg each will be delivered to customer.

Rabbit monoclonal antibody raised against a human XBP1 peptide using ARM Technology.

This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq

Library Construction: Nonfusion antibody library from rabbit spleen (ARM Technology)
Expression: Overexpression vector and transfection into 293H cell line

Order Info

1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.

Specifications

• Antigen: XBP1
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Concentration: 1mg
• Conjugate: Unconjugated
• Description: X-box binding protein 1
• Formulation: In 1X PBS, pH 7.4
• Gene: XBP1
• Gene Accession No.: XBP1
• Gene Alias: TREB5, XBP2
• Gene Symbols: XBP1
• Host Species: Rabbit
• Immunogen: A synthetic peptide of human XBP1
• Quantity: 1 mg x up to 3 Abs
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7494
• Target Species: Human
• Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG