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XPA Mouse anti-Human, Unlabeled, Clone: 12F5, BD

Catalog No. BDB556453 Shop All BD Biosciences Products
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BDB556453 0.1 mg
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Catalog No. BDB556453 Supplier BD Biosciences Supplier No. 556453

Description

Mouse Monoclonal Antibody

Nucleotide excision repair (NER) is a major pathway by which cells remove UV and chemically induced damage from DNA. The biochemistry of NER is complex and includes recognition of the damaged DNA, formation of incisions ∽26-29 nucleotides apart on each side of the damaged DNA, excision of an oligonucleotide carrying the damaged DNA, and synthesis of a repair patch using the opposite DNA strand as a template. The xeroderma pigmentosum (XP) factors are the best characterized components in the NER pathway. They are termed XP-A to -G and are thought to be required for the first steps of the nucleotide excision repair process. XPA is a DNA damage-binding protein and XPC is a single stranded DNA-binding protein. XPB and XPD are DNA helicases that are components of the transcription factor TFIIH. The TFIIH complex is thought to be involved in transcription and NER. XPF is an endonuclease that binds to ERCC1 (for excision repair cross-complementing) and the ERCC1-XPF complex makes the incision 5′ to the DNA damage. ERCC1 migrates at a molecular weight of ∽36kDa in SDS-PAGE. XPG is an endonuclease that makes the 3′ incision. XPA has been reported to migrate at a molecular weight of 34-40kDa in SDS-PAGE.

Host Species: Mouse
Clone: 12F5
Isotype: IgG2a κ
Species Reactivity: Human
Immunogen: Human XPA (His-tagged) Recombinant Protein

Immunoprecipitation, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen XPA
Applications Western Blot
Classification Monoclonal
Clone 12F5
Concentration 0.5mg/mL
Conjugate Unconjugated
Description Xeroderma Pigmentosum factor A
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human XPA (His-tagged) Recombinant Protein
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C
Isotype IgG2a κ
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For Research Use Only.

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