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anti-XPG/ERCC5, Clone: 8H7, Epredia™ LabVision

Mouse Monoclonal Antibody

Specifications

Antigen XPG/ERCC5 Ab-1
Classification Monoclonal
Conjugate Unconjugated
Form Purified
Host Species Mouse
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Products 4
Catalog Number Mfr. No. Conjugate Concentration Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Conjugate Concentration Quantity Price Quantity & Availability  
MS674P0
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Epredia
MS674P0
Unconjugated 200μg/mL 100 μL N/A N/A N/A
MS674P
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Epredia
MS674P
Unconjugated 200μg/mL 1 mL N/A N/A N/A
MS674P1ABX
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Epredia
MS674P1ABX
Unconjugated 1mg/mL 100 μL N/A N/A N/A
MS674PABX
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Epredia
MS674PABX
Unconjugated 1mg/mL 200 μL N/A N/A N/A
Description

Description

Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight. The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is an enzyme essential for DNA repair of the major kinds of solar ultraviolet (UV)-induced DNA damages. Human XPG nuclease makes the 3' incision during nucleotide excision repair of DNA. The enzyme cleaves model DNA bubble structures specifically near the junction of unpaired DNA with a duplex region. A 29-amino acid region of human XPG (residues 981-1009) contains the PCNA binding activity. A conserved arginine in XPG (Arg992) is crucial for its PCNA binding activity. Replication Protein A (RPA) binds specifically and directly to two excision repair proteins, the xeroderma pigmentosum damage-recognition protein XPA and the endonuclease XPG.

Host Species: Mouse
Clone: 8H7
Isotype: IgG2a/κ
Cross Reactivity: Human. Others-not known.
Epitope: Not determined
Immunogen: Recombinant human XPG protein.
Molecular Weight: 185kDa
Positive Control: Lncap cells.
Cellular Localization: Nuclear

Immunofluorescence, Western Blotting

Abbreviations: AP=Affinity Purification, ChIP=Chromatin IP, CM=Confocal Microscopy, DB=Dot Blot, EIA=ELISA, EM=Electron Microscopy, FC=Flow Cytometry, GS=Gel Supershift, IC=Immunocytochemistry, IF=Immunofluorescence, IH=Immunohistology/Immunohistochemistry, IP=Immunoprecipitation, IPK=IP Kinase Assay, KA=Kinase Assay, NEUT=Neutralization, PIA=Peptide Inhibition Assay, RIA=Radioimmunossay, TCA=T Cell Activation, WB=Western Blotting, Species: Am=Amphibian, Av=Avian, B=Bovine, Ca=Cat ,Ck=Chicken, D=Dog, Dr=Deer, Ds=Drosophila, El=Elk, Fg=Frog, Fs=Fish, Ft=Ferret, G=Goat, Gp=Guinea Pig, H=Horse, Hm=Hamster, Hu=Human, K=Kangaroo, Ms=Mouse, Nhp=Non-Human Primate, O=Ovine, P=Porcine, Rb=Rabbit, Rp=Reptile, Rt=Rat, Ys=Yeast, Xn=Xenopus, (wk)=cross reacts weakly

Specifications

Specifications

XPG/ERCC5 Ab-1
Unconjugated
Mouse
Recombinant human XPG protein.
Primary
Monoclonal
Purified
Human
IgG2a κ
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