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  6. anti-XPG/ERCC5, Clone: 8H7, Epredia™ LabVision

anti-XPG/ERCC5, Clone: 8H7, Epredia™ LabVision

Catalog No. p-3036384 Shop All Epredia Products
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Quantity:
100 μL
200 μL
1 mL
Concentration:
1mg/mL
200μg/mL
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Catalog No. Quantity Concentration
MS674P0 100 μL 200μg/mL
MS674P 1 mL 200μg/mL
MS674P1ABX 100 μL 1mg/mL
MS674PABX 200 μL 1mg/mL
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Catalog No. MS674P0 Supplier Epredia Supplier No. MS674P0

Description

Mouse Monoclonal Antibody

Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight. The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is an enzyme essential for DNA repair of the major kinds of solar ultraviolet (UV)-induced DNA damages. Human XPG nuclease makes the 3' incision during nucleotide excision repair of DNA. The enzyme cleaves model DNA bubble structures specifically near the junction of unpaired DNA with a duplex region. A 29-amino acid region of human XPG (residues 981-1009) contains the PCNA binding activity. A conserved arginine in XPG (Arg992) is crucial for its PCNA binding activity. Replication Protein A (RPA) binds specifically and directly to two excision repair proteins, the xeroderma pigmentosum damage-recognition protein XPA and the endonuclease XPG.

Host Species: Mouse
Clone: 8H7
Isotype: IgG2a/κ
Cross Reactivity: Human. Others-not known.
Epitope: Not determined
Immunogen: Recombinant human XPG protein.
Molecular Weight: 185kDa
Positive Control: Lncap cells.
Cellular Localization: Nuclear

Immunofluorescence, Western Blotting

Abbreviations: AP=Affinity Purification, ChIP=Chromatin IP, CM=Confocal Microscopy, DB=Dot Blot, EIA=ELISA, EM=Electron Microscopy, FC=Flow Cytometry, GS=Gel Supershift, IC=Immunocytochemistry, IF=Immunofluorescence, IH=Immunohistology/Immunohistochemistry, IP=Immunoprecipitation, IPK=IP Kinase Assay, KA=Kinase Assay, NEUT=Neutralization, PIA=Peptide Inhibition Assay, RIA=Radioimmunossay, TCA=T Cell Activation, WB=Western Blotting, Species: Am=Amphibian, Av=Avian, B=Bovine, Ca=Cat ,Ck=Chicken, D=Dog, Dr=Deer, Ds=Drosophila, El=Elk, Fg=Frog, Fs=Fish, Ft=Ferret, G=Goat, Gp=Guinea Pig, H=Horse, Hm=Hamster, Hu=Human, K=Kangaroo, Ms=Mouse, Nhp=Non-Human Primate, O=Ovine, P=Porcine, Rb=Rabbit, Rp=Reptile, Rt=Rat, Ys=Yeast, Xn=Xenopus, (wk)=cross reacts weakly

Specifications

Antigen XPG/ERCC5 Ab-1
Classification Monoclonal
Concentration 200μg/mL
Conjugate Unconjugated
Host Species Mouse
Immunogen Recombinant human XPG protein.
Quantity 100 μL
Primary or Secondary Primary
Target Species Human
Form Purified
Isotype IgG2a κ
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