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Zap70 (pY292) Mouse anti-Human, Alexa Fluor 647, Clone: J34-602, BD

Catalog No. BDB558515 Shop All BD Biosciences Products
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BDB558515 50 Tests
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Catalog No. BDB558515 Supplier BD Biosciences Supplier No. 558515

Description

Mouse Monoclonal Antibody

The 70kDa ζchain-associated protein (ZAP70) is a Syk-family protein tyrosine kinase (PTK) that associates with the ζ subunit of the T cell antigen receptor (TCR) and undergoes tyrosine phosphorylation following TCR stimulation. ZAP70 contains two SH2-like domains with the PTK domain located at the C-terminus. TCR-mediated Lck activity leads to phosphorylation of ZAP70 on Tyrosine 493 in the regulatory loop of the PTK domain leading to upregulation of ZAP70 kinase activity. Tyrosine 292 (Y292), in the linker region between the SH2 and PTK domains, is autophosphorylated by the activated PTK domain. By binding with c-Cbl, the phosphorylated Y292 can down-regulate TCR signaling. The J34-602 antibody recognizes ZAP70 phosphorylated at Y292.

Intracellular Staining

TRUSTED_SUSTAINABILITY

Specifications

Antigen Zap70 (pY292)
Applications Flow Cytometry
Classification Monoclonal
Clone J34-602
Conjugate Alexa Fluor 647
Description ZAP-70 (pY292)
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Phosphorylated Human ZAP70
Purification Method Affinity Purified
Quantity 50 Tests
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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