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ZRP-1 Mouse, Unlabeled, Clone: 16, BD

Catalog No. BDB612254 Shop All BD Biosciences Products
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BDB612254 50 μg
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Catalog No. BDB612254 Supplier BD Biosciences Supplier No. 612254

Description

Mouse Monoclonal Antibody

Zyxin is a zinc-binding metalloprotein found in focal adhesion plaques. It contains a proline-rich N-terminal domain and a C-terminal domain containing three LIM domains. LIM domains are characterized as zinc-binding motifs involved in gene expression and protein-protein interactions. Zyxin related protein 1 (ZRP-1) was identified through its interaction with the second PDZ domain of PTP1E. ZRP-1 has also been identified as Thyroid Receptor Interacting Protein-6 (TRIP6) during screening for binding partners of the thyroid hormone receptor.
ZRP-1 contains an N-terminal proline-rich region (PRR), and three double zinc finger LIM domains in the C-terminal region. ZRP-1 mRNA has been reported to be widely expressed with strong expression in heart, placenta, lung, liver, kidney, and pancreas. ZRP-1 may interact with focal adhesions similar to other LIM domain proteins in the zyxin-related subfamily. However, ZRP-1 also contains nuclear export signal, and treatment of cells with leptomycin B leads to movement of ZRP-1 from the cytoplasm to the nucleus. Thus, ZRP-1 may be important for relaying signals from focal adhesions to the nucleus.

Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen ZRP-1
Applications Western Blot
Classification Monoclonal
Clone 16
Concentration 250μg/mL
Conjugate Unconjugated
Description Zyxin Related Protein-1; TRIP6; Thyroid Receptor Interacting Protein-6
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human ZRP-1 aa. 103-209
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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For Research Use Only.

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