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Invitrogen™ AOX1 Polyclonal Antibody
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Catalog No. PIPA5119973
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100 μL
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PIPA5119973 100 μL
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Catalog No. PIPA5119973 Supplier Invitrogen™ Supplier No. PA5119973
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Description

Rabbit Polyclonal Antibody

Positive Control: Mouse liver tissue lysate, rat liver tissue lysate, human liver carcinoma tissue, human liver tissue, Hela. Subcellular Location: Cytoplasm.

AOX1 (Aldehyde oxidase 1) is a 1338 amino acid cytoplasmic protein that catalyzes the oxidation of a variety of aldehydes, leading to the production of hydrogen peroxide. Under certain conditions, AOX1 can catalyze the formation of the superoxide free radical. Defects in oxygen radical metabolism have been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS), an autosomal dominant neurodegenerative disorder characterized by the death of motor neurons in the spinal cord, brain and brainstem. Significantly, AOX1 is highly expressed in the ventral horn of the spinal cord and the gene that encodes AOX1 is located in a chromosomal region that is frequently found to be implicated in ALS2. This evidence suggests that AOX1 is a candidate gene for ALS2.
TRUSTED_SUSTAINABILITY

Specifications

Antigen AOX1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
Gene AOX1
Gene Accession No. O54754, Q06278, Q9Z0U5
Gene Alias AI196512; AI255253; Aldehyde oxidase; aldehyde oxidase (female form); aldehyde oxidase 1; aldehyde oxidase 2; Ao; AOH1; Aox1; Aox-1; Aox2; Aox-2; Azaheterocycle hydroxylase; azaheterocycle hydroxylase 1; Moro; Retinal oxidase; Ro
Gene Symbols AOX1
Host Species Rabbit
Immunogen Synthetic peptide within human Aldehyde Oxidase aa 1,250-1,280.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11761, 316, 54349
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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