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R&D Systems™ AP 1867 PEG3 Haloalkane
SDP

Catalog No. RD10193523 Shop All Novus Products
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5 mg
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RD10193523 5 mg
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Catalog No. RD10193523 Supplier R&D Systems™ Supplier No. 8988/5

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Description

A Tocris product, part of R&D Systems.

AP 1867 PEG3 Haloalkane is a heterobifunctional molecule inducing proximity between a Ser/Thr phosphatase (PP2) fused with FKBP12 (F36V) and a phosphosubstrate (PDCD4 and FOXO3a) fused with haloalkane dehalogenase and affecting dephosphorylation of the latter (PhosTAC). In pulldown experiments, AP 1867 PEG3 Haloalkane induces 50% dephosphorylation of PDCD4 at 10μM after 12 h incubation. Targeted protein dephosphorylation with AP 1867 PEG3 Haloalkane can be used to induce dephosphorylation of other haloalkane dehalogenase labeled phosphoproteins.

Specifications

Chemical Name or Material [(1R)-1-[3-[2-[2-[2-[2-(6-Chlorohexoxy)ethoxy]ethoxy]ethylamino]-2-oxoethoxy]phenyl]-3-(3,4-dimethoxyphenyl)propyl] (2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carboxylate
Quantity 5 mg
Product Line Tocris
Target Protein Ser/Thr Phosphatase Activators
Molecular Formula C50H71ClN2O13
Purity 98%
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