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Tocris Bioscience™ AP 20187
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Catalog No. 62975
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Quantity:
5 mg
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This item is not returnable. View return policy

Description

Chemical inducer of protein dimerization; active in vivo

AP 20187 is a chemical inducer of dimerization (CID) for use in FKBP fusion protein systems. Induces apoptosis in cells expressing fusion proteins consisting of FKBPF36V and the intracellular domain of the Fas receptor, Fas-associated death domain (FADD) or a caspase. Selective for FKBPF36V-Fas fusion proteins over wild-type FKBP. Induces apoptosis of senescent cells expressing caspase-8-FKBP fusion proteins under the control of an Ink4a promoter. Active in vivo.

Specifications

Chemical Name or Material 2,2 '-[[2-[(Dimethylamino)methyl]-1,3-propanediyl]bis[imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene[(1 R)-3-(3,4-dimethoxyphenyl)propylidene]]] bis[1-[(2 S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate]
CAS 195514-80-8
Quantity 5 mg
Target Protein Dimerizers
Molecular Formula C82H107N5O20
Purity 0.98
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