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  5. Tocris Bioscience™ AP C5

Tocris Bioscience™ AP C5
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Catalog No. 662650
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66-265-0 50 mg
66-261-0 10 mg
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Catalog No. 66-265-0 Supplier Tocris Bioscience™ Supplier No. 6626/50
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Description

Potent and selective PKG2 inhibitor

AP C5 is a potent and selective protein kinase G type II (PKG2) inhibitor (pIC50 = 7.2). Displays >20-fold selectivity for PKG2 over PKG1 and PKA (pIC50 values are 4.6 and 4.8 for PKG1 and PKA, respectively). Blocks 8-pCPT-cGMP-dependent VASP phosphorylation in intestinal organoids. Also attenuates toxin-stimulated anion secretory responses in mouse intestinal tissue.

Specifications

Chemical Name or Material 4-[4-(1H-Imidazol-1-yl)phenyl]-N-2-propyn-1-yl-2-pyrimidinamine
CAS 2234272-10-5
Quantity 50 mg
Molecular Formula C16H13N5
Formula Weight 275.31
Purity 98%
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