AP2M1 Mouse anti-Canine, Human, Rat, Clone: OTI 2F11, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF503021

Catalog No. 50-166-1815

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

The heterotetrameric coat assembly protein complex, also known as the adaptor-related protein complex 2 (AP-2), belongs to the adaptor complexes medium subunits family. The mu 1 subunit of the AP-2 complex (AP2M1) is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. AP2M1 has also been shown to associate with the HIV-1 protein Nef, suggesting that Nef may use AP-2 complex to enhance the rate of endocytosis of both CD4 and class I MHC. AP2M1 may also play an important role in regulating the intracellular trafficking and function of cytotoxic T-lymphocyte associated (CTLA)-4 protein. At least two isoforms of AP2M1 are known to exist.

Specifications

• Antigen: AP2M1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: AP2M1
• Gene Alias: AP50, CLAPM1, mu2
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116563, 1173, 607139
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI 2F11
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P84092, Q96CW1
• Gene Symbols: Ap2m1
• Immunogen: Human recombit protein fragment corresponding to amino acids 97-383 of human AP2M1 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Canine, Human, Rat
• Product Type: Antibody
• Isotype: IgG1