AP2M1 Mouse anti-Human, Mouse, Clone: OTI2G2, liquid, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene TA503017
DescriptionThe heterotetrameric coat assembly protein complex, also known as the adaptor-related protein complex 2 (AP-2), belongs to the adaptor complexes medium subunits family. The mu 1 subunit of the AP-2 complex (AP2M1) is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. AP2M1 has also been shown to associate with the HIV-1 protein Nef, suggesting that Nef may use AP-2 complex to enhance the rate of endocytosis of both CD4 and class I MHC. AP2M1 may also play an important role in regulating the intracellular trafficking and function of cytotoxic T-lymphocyte associated (CTLA)-4 protein. At least two isoforms of AP2M1 are known to exist.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide|
|AP50, CLAPM1, mu2|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Western Blot|
|Human recombit protein fragment corresponding to amino acids 97-383 of human AP2M1 produced in E.coli.|
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