Invitrogen™ AP2M1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120244

Catalog No. PIPA5120244

Description

Positive test controls include: HeLa, Mouse brain, Rat brain . The target is usually found in the following locations: Cell membrane, Cytoplasmic side, Membrane, Peripheral membrane protein, coated pit. Immunogen sequence: TQQGIKSQHQ TKEEQSQITS QVTGQIGWRR EGIKYRRNEL FLDVLESVNL LMSPQGQVLS AHVSGRVVMK SYLSGMPECK FGMNDKIVIE KQGKGTADET SKSGKQSIAI DDCTFHQCVR LSKFDSERSI SFIPPDGEFE LMRYRTTKDI ILPFRVIPLV REVGRTKLEV KVVIKSNFKP SLLAQKIEVR IPTPLNTSGV QVICMKGKAK YKASENAIVW KIKRMAGMKE SQISAEIELL PTNDKKKWAR PPISMNFEVP FAPSGLKVRY LKVFEPKLNY SDHDVIKWVR YIGRSGIYET.

The heterotetrameric coat assembly protein complex, also known as the adaptor-related protein complex 2 (AP-2), belongs to the adaptor complexes medium subunits family. The mu 1 subunit of the AP-2 complex (AP2M1) is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. AP2M1 has also been shown to associate with the HIV-1 protein Nef, suggesting that Nef may use AP-2 complex to enhance the rate of endocytosis of both CD4 and class I MHC. AP2M1 may also play an important role in regulating the intracellular trafficking and function of cytotoxic T-lymphocyte associated (CTLA)-4 protein. At least two isoforms of AP2M1 are known to exist.

Specifications

• Antigen: AP2M1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: AP2M1
• Gene Alias: adapter-related protein complex 2 mu subunit; adapter-related protein complex 2 subunit mu; adaptin-mu2; Adaptor protein complex AP-2 subunit mu; adaptor related protein complex 2 mu 1 subunit; adaptor related protein complex 2 subunit mu 1; adaptor related protein complex 2, mu 1 subunit; adaptor-related protein complex 2 subunit mu; adaptor-related protein complex 2, mu 1 subunit; AP-2 complex subunit mu; AP-2 mu 2 chain; AP-2 mu chain; Ap2m1; AP50; Clapm1; clathrin adaptor complex AP2, mu subunit; Clathrin assembly protein complex 2 medium chain; clathrin assembly protein complex 2 mu medium chain; clathrin coat adaptor protein AP50; Clathrin coat assembly protein AP50; Clathrin coat-associated protein AP50; clathrin-associated/assembly/adaptor protein, medium 1; coat assembly protein complex 50 kD; HA2 50 kDA subunit; KIAA0109; mu2; Mu2-adaptin; Plasma membrane adaptor AP-2 50 kDa protein; plasma membrane adaptor AP-2 50kDA protein; QtsA-16673; unnamed protein product
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116563, 1173, 11773
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.43 mg/mL
• Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene Accession No.: P84091, P84092, Q96CW1
• Gene Symbols: AP2M1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 134-433 of human AP2M1 (NP_004059.2).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov