Invitrogen™ AP2S1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA550327

Catalog No. PA550327

Description

The antibody detects endogenous levels of total AP2S1 protein.

Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif. May also play a role in extracellular calcium homeostasis.

Specifications

• Antigen: AP2S1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: AP2S1
• Gene Alias: adapter-related protein complex 2 sigma subunit; adapter-related protein complex 2 subunit sigma; adaptor protein complex AP-2 subunit sigma; adaptor related protein complex 2 sigma 1 subunit; adaptor-related protein complex 2 sigma 1 subunit; adaptor-related protein complex 2 subunit sigma; adaptor-related protein complex 2, sigma 1 subunit; AI043088; Ap17; AP17-DELTA; AP-2 complex subunit sigma; AP2S1; Claps2; Clathrin assembly protein 2 sigma small chain; clathrin assembly protein 2 small chain; clathrin coat assembly protein AP17; Clathrin coat-associated protein AP17; clathrin-associated protein 17; clathrin-associated/assembly/adaptor protein, small 2 (17kD); FBH3; FBHOk; HA2 17 kDa subunit; HHC3; Plasma membrane adaptor AP-2 17 kDa protein; Sigma2-adaptin; sigma-adaptin 3b
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1175, 232910, 65046
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.9 mg/mL
• Formulation: PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P53680, P62743, P62744
• Gene Symbols: AP2S1
• Immunogen: Full length fusion protein of Human AP2S1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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