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Invitrogen™ APAF1 Polyclonal Antibody
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Catalog No. PIPA586106
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100 μL
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Catalog No. Quantity
PIPA586106 100 μL
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Catalog No. PIPA586106 Supplier Invitrogen™ Supplier No. PA586106
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Description

Rabbit Polyclonal Antibody

Purity is > 95% by SDS-PAGE.

APAF1 gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.
TRUSTED_SUSTAINABILITY

Specifications

Antigen APAF1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene APAF1
Gene Accession No. O14727, O88879, Q9EPV5
Gene Alias 6230400I06Rik; APAF1; APAF-1; Apaf1l; apoptotic peptidase activating factor 1; apoptotic protease activating factor 1; apoptotic protease-activating factor 1; CED4; DKFZp781B1145; fog; forebrain overgrowth; KIAA0413; mKIAA0413
Gene Symbols APAF1
Host Species Rabbit
Immunogen Synthetic peptide, corresponding to amino acids 301-350 of Human Apaf-1-ALT.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11783, 317, 78963
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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