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Invitrogen™ APAF1 Polyclonal Antibody, Invitrogen™
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Catalog No. FEPA5145497
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200 μL
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FEPA5145497 200 μL
FEPA5145498 20 μL
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Catalog No. FEPA5145497 Supplier Invitrogen™ Supplier No. PA5145497
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Description

Rabbit Polyclonal Antibody

APAF1 gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.
TRUSTED_SUSTAINABILITY

Specifications

Antigen APAF1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% Proclin 300; pH 7.4
Gene APAF1
Gene Accession No. O88879, Q9EPV5
Gene Alias 6230400I06Rik; APAF1; APAF-1; Apaf1l; apoptotic peptidase activating factor 1; apoptotic protease activating factor 1; apoptotic protease-activating factor 1; CED4; DKFZp781B1145; fog; forebrain overgrowth; KIAA0413; mKIAA0413
Gene Symbols APAF1
Host Species Rabbit
Immunogen Recombinant Mouse APAF1 protein, Arg872-Phe1135 (Accession #O88879).
Purification Method Antigen affinity chromatography, Protein A
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11783, 78963
Target Species Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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