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APAF1 Polyclonal Antibody, Invitrogen™

Catalog No. 01674172
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Catalog No. Quantity
01-674-172 100 μg
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Catalog No. 01-674-172 Supplier Thermo Scientific Supplier No. PA112512

Description

Rabbit Polyclonal Antibody

A suggested positive control for this product is HeLa whole cell lysate.

APAF1 gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.
TRUSTED_SUSTAINABILITY

Specifications

Antigen APAF1
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene APAF1
Gene Accession No. O14727, O88879, Q9EPV5
Gene Alias 6230400I06Rik; APAF1; APAF-1; Apaf1l; apoptotic peptidase activating factor 1; apoptotic protease activating factor 1; apoptotic protease-activating factor 1; CED4; DKFZp781B1145; fog; forebrain overgrowth; KIAA0413; mKIAA0413
Gene Symbols APAF1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues 12-28 of the human Apaf-1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11783, 317, 78963
Target Species Human, Mouse, Rat
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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