Invitrogen™ APBA1 Polyclonal Antibody

Catalog No.	Quantity
PIPA5114856	100 μL

Catalog No. PIPA5114856 Supplier Invitrogen™ Supplier No. PA5114856

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total APBA1.

The munc-18 interacting protein (Mint) protein family is a group of evolutionarily conserved adaptor proteins that function in membrane transport and organization. In mammals, there exist three Mint isoforms, Mint1, 2, and 3. Although there is little amino acid sequence conservation in the amino-terminal half, the carboxy-terminal half of these proteins is highly conserved. Within this conserved portion there exists a phosphotyrosine-binding (PTB) and a PSD-95/DLG-A/ZO-1 (PDZ) domain, which function as protein interaction modules. Mint1 and 2 appear to be expressed exclusively in the brain and are found to bind to Munc18, an essential component of the synaptic vesicle fusion machinery. Mint3 is ubiquitously expressed in all tissues and is expressed at the lowest levels in the brain and testis. Studies show that mint3 does not interact with munc-18. Mint3 has been found to interact with the Alzheimer's Disease-related amyloid precursor protein (APP) and does so through its PTB and PDZ domains. It has been suggested that mint3 links APP to other transport machinery components, thereby regulating it transport, endocytosis, and metabolism. Abnormal APP metabolism has been shown to be the cause of an early-onset type of Alzheimer's disease.

Specifications

• Antigen: APBA1
• Applications: Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene: APBA1
• Gene Accession No.: B2RUJ5, O35430, Q02410
• Gene Alias: 6430513E09Rik; adapter protein X11alpha; adaptor protein X11alpha; amyloid beta (A4) precursor protein binding, family A, member 1; amyloid beta (A4) precursor protein-binding family A APBA1: amyloid beta (A4) precursor protein-binding family A member 1 (X11); amyloid beta (A4) precursor protein-binding, family A, APBA1: amyloid beta (A4) precursor protein-binding, family A, member 1 (X11); amyloid beta (A4) precursor protein-binding, family A, member 1; amyloid beta (A4) precursor protein-binding, family A, member 1 (X11); amyloid beta A4 precursor protein-binding family A member 1; amyloid beta precursor protein binding family A member 1; Amyloid-beta A4 precursor protein-binding family A member 1; APBA1; D9S411E; LIN10; Lin-10; Mint; MINT1; Mint-1; neuronal Munc18-1-interacting protein 1; Neuron-specific X11 protein; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; Urop11; UROP11-110; X11; X11A; X11ALPHA
• Gene Symbols: APBA1
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from human APBA1(Accession Q02410), corresponding to amino acid residues M1-H31.
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 319924, 320, 83589
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG