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Invitrogen™ APC-AAT complexes Monoclonal Antibody (7)
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Catalog No. ABS0010702
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400 μL
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Catalog No. Quantity
ABS0010702 400 μL
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Catalog No. ABS0010702 Supplier Invitrogen™ Supplier No. ABS0010702
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Description

Mouse Monoclonal Antibody

ABS 001-07-02 has specificity for a conformation-dependant neoepitope that is expressed in activated protein C upon complex-formation with alpha1-antitrypsin. No reaction is seen to non-complexed alpha1-antitrypsin and only very little cross reaction to protein C zymogen. Note that specificity is calcium dependent. ABS 001-07-02 has been successfully used in ELISA procedures. ABS 001-07-02 reacts strongly with APC-AAT complexes in ELISA. It can be used in sandwich ELISA in combination with a polyclonal anti-protein C antiserum. Note, that the conformational neoepitope expressed in the complex can also be expressed in APC coated directly onto a high-binding microtiter plate. The epitope specificity of ABS 001-07-02 is not determined. NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL.

The neoepitope is conformation-dependent and expressed in activated protein C upon complex-formation with α1-antitrypsin. Protein C is a vitamin K-dependent serine protease produced in the liver and made up of 2 polypeptide chains. The 62 kDa proenzyme is activated by thrombin and the active enzyme cleaves factor Va and VIIIa and thus inhibits blood coagulation. The molecular weight of the active enzyme is 55 kDa and the normal concentrations in human plasma is approximately 1-3 ng/mL because of the very fast turnover, the proenzyme concentration is approximately 3 μg/mL. The activated protein C (APC) is inhibited by members of the serine protease inhibitor (serpin) family, of which α1-antitrypsin (AAT) and protein C inhibitor (PCI) are the most important.
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Specifications

Antigen APC-AAT complexes
Applications ELISA, Immunohistochemistry
Classification Monoclonal
Clone 7
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 15mM sodium azide; pH 7.4
Gene Alias AAT; APC
Host Species Mouse
Immunogen Recombinant form of human activated protein C.
Purification Method Protein A/G
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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