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Invitrogen™ APC1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA520941
Description
A suggested positive control is SK-N-SH cell lysate. PA5-20941 can be used with blocking peptide PEP-1055.
Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC1, also known as mitotic checkpoint regulator (MCPR), is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex.
Specifications
APC1 | |
Polyclonal | |
Unconjugated | |
ANAPC1 | |
2610021O03Rik; AI047775; AI853536; ANAPC1; anaphase promoting complex subunit 1; anaphase-promoting complex 1 (meiotic checkpoint regulator); anaphase-promoting complex subunit 1; APC1; AW547281; Cyclosome subunit 1; Mcpr; meiotic check point regulator; mitotic checkpoint regulator; Testis-specific gene 24 protein; TSG24 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
17222, 64682 | |
Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C | |
Liquid |
Immunohistochemistry, Western Blot | |
1 mg/mL | |
PBS with 0.02% sodium azide | |
P53995, Q9H1A4 | |
ANAPC1 | |
A 17 amino acid peptide near the carboxy terminus of human APC1. | |
100 μg | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
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