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Invitrogen™ APC1 Polyclonal Antibody
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Catalog No. PIPA583639
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PIPA583639 100 μL
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Catalog No. PIPA583639 Supplier Invitrogen™ Supplier No. PA583639
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: DLSKGTQHLK SILSKDGVLY VKLRAGQLSY KEDPMGWQSL LAQTVANRNS EARAFKPETI SAFTSDPALL SFAEYFCKPT VNMGQKQEIL DLFSSV Highest antigen sequence indentity to the following orthologs: Mouse - 94%, Rat - 95%.

Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC1, also known as mitotic checkpoint regulator (MCPR), is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex.
TRUSTED_SUSTAINABILITY

Specifications

Antigen APC1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ANAPC1
Gene Accession No. Q9H1A4
Gene Alias 2610021O03Rik; AI047775; AI853536; ANAPC1; anaphase promoting complex subunit 1; anaphase-promoting complex 1 (meiotic checkpoint regulator); anaphase-promoting complex subunit 1; APC1; AW547281; Cyclosome subunit 1; Mcpr; meiotic check point regulator; mitotic checkpoint regulator; Testis-specific gene 24 protein; TSG24
Gene Symbols ANAPC1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human ANAPC1. Recombinant protein control fragment (Product #RP-102931).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 64682
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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