Invitrogen™ APC1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA583639

Catalog No. PIPA583639

Description

Immunogen sequence: DLSKGTQHLK SILSKDGVLY VKLRAGQLSY KEDPMGWQSL LAQTVANRNS EARAFKPETI SAFTSDPALL SFAEYFCKPT VNMGQKQEIL DLFSSV.

Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC1, also known as mitotic checkpoint regulator (MCPR), is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex.

Specifications

• Antigen: APC1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ANAPC1
• Gene Alias: 2610021O03Rik; AI047775; AI853536; ANAPC1; anaphase promoting complex subunit 1; anaphase-promoting complex 1 (meiotic checkpoint regulator); anaphase-promoting complex subunit 1; APC1; AW547281; Cyclosome subunit 1; Mcpr; meiotic check point regulator; mitotic checkpoint regulator; Testis-specific gene 24 protein; TSG24
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 64682
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9H1A4
• Gene Symbols: ANAPC1
• Immunogen: Recombinant protein corresponding to Human ANAPC1. Recombinant protein control fragment (Product #RP-102931).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov