Invitrogen™ APC10 Monoclonal Antibody (3E9A9)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA531622

Catalog No. PIMA531622

Description

MA5-31622 has been tested in indirect ELISA.

Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC10 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. It has been suggested that APC10 plays a role to regulate the binding of specific substrates to the APC/C complex, similar to that of coactivators.

Specifications

• Antigen: APC10
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% sodium azide
• Gene Accession No.: Q9UM13
• Gene Symbols: ANAPC10
• Immunogen: Purified recombinant fragment of human ANAPC10 (AA: 1-185) expressed in E. coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: 3E9A9
• Conjugate: Unconjugated
• Gene: ANAPC10
• Gene Alias: 1500026N15Rik; A830003M23Rik; ANAPC10; anaphase promoting complex subunit 10; anaphase-promoting complex subunit 10; APC10; cyclosome subunit 10; DKFZp564L0562; DOC1
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 10393
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid