Invitrogen™ APC10 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520950

Catalog No. PIPA520950

Description

A suggested positive control is mouse heart tissue lysate. PA5-20950 can be used with blocking peptide PEP-1064.

Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC10 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. It has been suggested that APC10 plays a role to regulate the binding of specific substrates to the APC/C complex, similar to that of coactivators.

Specifications

• Antigen: APC10
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ANAPC10
• Gene Alias: 1500026N15Rik; A830003M23Rik; ANAPC10; anaphase promoting complex subunit 10; anaphase-promoting complex subunit 10; APC10; cyclosome subunit 10; DKFZp564L0562; DOC1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10393, 361389, 68999
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q8K2H6, Q9UM13
• Gene Symbols: ANAPC10
• Immunogen: A 16 amino acid peptide near the center of human APC10.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG