APC10 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-2274	100 μL

Catalog No. 50-198-2274 Supplier Bioss Supplier No. BS12483R

Description

Rabbit Polyclonal Antibody

Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC10 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. It has been suggested that APC10 plays a role to regulate the binding of specific substrates to the APC/C complex, similar to that of coactivators.

Specifications

• Antigen: APC10
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: ANAPC10
• Gene Accession No.: Q9UM13
• Gene Alias: 1500026N15Rik; A830003M23Rik; ANAPC10; anaphase promoting complex subunit 10; Anaphase-promoting complex subunit 10; Apc10; Cyclosome subunit 10; DKFZp564L0562; DOC1
• Gene Symbols: ANAPC10
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human APC10.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10393
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG