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APC11, Mouse anti-Human, Clone: CRQ1.1, Millipore Sigma™

Catalog No. MABE178925 Shop All MilliporeSigma Products
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MABE178925 25 μg
MABE1789100 100 μg
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Catalog No. MABE178925 Supplier MilliporeSigma Supplier No. MABE178925UG
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Description

Mouse Monoclonal Antibody

Anti-APC11, clone CRQ1.1, Cat. No. MABE1789, is a highly specific mouse monoclonal antibody that targets Anaphase-promoting complex subunit 11 and has been tested in Western Blotting.

Anaphase-promoting complex subunit 11 (UniProt: Q9NYG5; also known as APC11, Cyclosome subunit 11, Hepatocellular carcinoma-associated RING finger protein) is encoded by the ANAPC11 (also known as HSPC214) gene (Gene ID: 51529) in human. APC11 is one of the components of the anaphase-promoting complex (APC) that belongs to the RING-box family of proteins. APC is a large E3 ubiquitin ligase that responsible for targeting proteins for degradation during mitosis. The APC is assembled from 13 different proteins where in APC2 binds to APC11 forming the catalytic core that recruits the E2 ubiquitin conjugating enzyme. APC11 has with multiple zinc -binding sites with a RING-type zinc-finger domain (aa 34-77). It is expressed at high levels in the skeletal muscle and heart and in moderate levels in brain, kidney, and liver. Two isoforms of APC11 have been described that are produced by alternative splicing. (Ref.: Schreiber, A et al., (2011). Nature. 470(7333); 227-32).
TRUSTED_SUSTAINABILITY

Specifications

Antigen APC11
Applications Western Blot
Classification Monoclonal
Clone CRQ1.1
Conjugate Unconjugated
Dilution Western Blotting Analysis: A representative lot detected APC11 in Western Blotting applications (Sedgwick, G.G., et. al. (2013). EMBO J. 32(2):303-14).Western Blotting Analysis: A representative lot detected APC11 in APC11-Flag expressed in HeLa cells following tetracycline treatment.
Formulation Purified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Alias Anaphase-promoting complex subunit 11;Cyclosome subunit 11;Hepatocellular carcinoma-associated RING finger protein
Gene Symbols ANAPC11;HSPC214
Host Species Mouse
Immunogen A linear peptide corresponding to 9 amino acids from the C-terminal region of human Anaphase-promoting complex subunit 11 (APC11).
Molecular Weight of Antigen 9.84 kDa calculated.
Purification Method Protein G purified
Quantity 25 μg
Regulatory Status RUO
Research Discipline Epigenetics & Nuclear Function
Primary or Secondary Primary
Gene ID (Entrez) NP_001002244.1
Test Specificity Clone CRQ1.1 specifically detects human Anaphase-promoting complex subunit 11 (APC11). It targets an epitope with in 9 amino acids from the C-terminal region.
Target Species Human
Content And Storage Stable for 1 year at 2-8°C from date of receipt.
Form Purified
Isotype IgG2a κ
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