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APC11 Mouse anti-Human, Clone: OTI3F5, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526263

Catalog No. PIMA526263


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Description

Description

Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC11 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. APC11, together with APC2 and Ubc4, form the minimal APC ubiquitin ligase module.
Specifications

Specifications

APC11
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q9NYG5
HSPC214, APC11, Apc11p; APC11 anaphase promoting complex subunit 11 homolog; anaphase promoting complex subunit 11 (yeast APC11 homolog); anaphase-promoting complex subunit 11; cyclosome subunit 11; hepatocellular carcinoma-associated RING finger protein
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
51529
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI3F5
Unconjugated
ANAPC11
Liquid
ANAPC11
Full length human recombit protein of ANAPC11 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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