APC11Rabbit anti-Human, Polyclonal, Rockland™

Rabbit Polyclonal Antibody

Supplier:  Rockland Immunochemicals 100401A15

Catalog No. 50-199-0100

Description

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. This product reacts with human and mouse APC11. Cross reactivity may also occur with APC11 from other sources. Sufficient sequence differences exist to suggest that this antibody would not react with other RING box proteins such as ROC1 and ROC2.

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

Specifications

• Antigen: APC11
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ANAPC11
• Gene Alias: 1110011I19Rik; ANAPC11; anaphase promoting complex subunit 11; anaphase promoting complex subunit 11 (yeast APC11 homolog); anaphase promoting complex subunit 11 homolog; Anaphase-promoting complex subunit 11; APC11; APC11 anaphase promoting complex subunit 11 homolog; Apc11p; Cyclosome subunit 11; Hepatocellular carcinoma-associated RING finger protein; HSPC214; R75218; RGD1561880
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody

• Applications: ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
• Concentration: 85 mg/mL
• Formulation: Antibody with 0.01% sodium azide; pH
• Gene Accession No.: Q9NYG5
• Gene Symbols: ANAPC11
• Immunogen: This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 76-84 of Human APC11 (C-terminal) coupled to KLH.
• Regulatory Status: RUO
• Gene ID (Entrez): 51529
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid