Invitrogen™ APC13 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5100739

Catalog No. PIPA5100739

Description

Antibody detects endogenous levels of total ANAPC13.

Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC13 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. APC13 promotes the stable association of APC3/Cdc27 and APC6/Cdc16 with the APC/C.

Specifications

• Antigen: APC13
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ANAPC13
• Gene Alias: 1810004D07Rik; ANAPC13; anaphase promoting complex subunit 13; anaphase-promoting complex subunit 13; APC13; cyclosome subunit 13; cylosome subunit 13; SWM1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 25847, 69010
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q8R034, Q9BS18
• Gene Symbols: ANAPC13
• Immunogen: A synthesized peptide derived from human ANAPC13(Accession Q9BS18), corresponding to amino acid residues I15-L65.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov